Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a diverse group of cancers that develop in B or T lymphocytes.
- Often, lymph nodes in the neck, under the arms, or in the groin enlarge rapidly and painlessly.
- People may have pain or shortness of breath or other symptoms when enlarged lymph nodes press on organs.
- A lymph node biopsy is needed for diagnosis.
- Treatment may involve radiation therapy, chemotherapy, monoclonal antibodies, or a combination.
- Most people are cured or survive for many years.
This group of cancers is actually more than 20 different diseases, which have distinct appearances under the microscope, different cell patterns, and different clinical courses. Most non-Hodgkin lymphomas (85%) are from B cells. Less than 15% develop from T cells. Non-Hodgkin lymphoma is more common than Hodgkin lymphoma. In the United States, about 65,000 new cases are diagnosed every year, and the number of new cases is increasing, especially among older people and people whose immune system is not functioning normally. People who have had organ transplants and some people who have been infected with the human immunodeficiency virus (HIV) are at risk of developing non-Hodgkin lymphoma.
Although the cause of non-Hodgkin lymphomas is not known, evidence strongly supports a role for viruses in some of the less common types. A rare type of rapidly progressive non-Hodgkin lymphoma, which occurs in southern Japan and the Caribbean, may result from infection with human T-cell lymphotropic virus 1 (HTLV-1), a retrovirus similar to HIV. The Epstein-Barr virus is associated with many cases of Burkitt's lymphoma, another type of non-Hodgkin lymphoma.
SymptomsThe first symptom is often rapid and usually painless enlargement of lymph nodes in the neck, under the arms, or in the groin. Enlarged lymph nodes within the chest may press against airways, causing cough and difficulty in breathing. Deep lymph nodes within the abdomen may press against various organs, causing loss of appetite, constipation, abdominal pain, or progressive swelling of the legs.
Since some lymphomas can appear in the bloodstream and bone marrow, people can develop symptoms related to too few red blood cells, white blood cells, or platelets. Too few red blood cells can cause anemia, leading to fatigue, shortness of breath, and pale skin. Too few white blood cells can lead to infections. Too few platelets may lead to increased bruising or bleeding. Non-Hodgkin lymphomas also commonly invade the bone marrow, digestive tract, skin, and occasionally the nervous system, causing various symptoms. Some people have persistent fever without an evident cause, the so-called fever of unknown origin. This type of fever commonly reflects an advanced stage of disease.
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذه الصورة] Diagnosis and ClassificationDoctors do a biopsy of an enlarged lymph node to diagnose non-Hodgkin lymphomas and to distinguish them from Hodgkin lymphoma and other disorders that cause enlarged lymph nodes.
Although more than 20 different disorders can be called non-Hodgkin lymphomas, doctors sometimes group them into two broad categories.
Indolent lymphomas are characterized by
- A long survival period (many years)
- Rapid response to many treatments
- Lack of cure when standard therapies are used
Aggressive lymphomas are characterized by
- Rapid progression without therapy
- High rates of cure with standard chemotherapy
Although non-Hodgkin lymphomas are usually diseases of middle-aged and older people, children and young adults may develop lymphomas, and lymphomas that develop in children and young adults are commonly aggressive subtypes.
Staging
Many people with non-Hodgkin lymphomas have disease that has spread at the time of diagnosis. In only 10 to 30% of people, the disease is limited to one region. People with these lymphomas undergo similar staging procedures as people with Hodgkin lymphoma . In addition, a bone marrow biopsy is almost always done.
Treatment and PrognosisFor some people with indolent lymphomas, treatment is not needed. Almost everyone else benefits from treatment. For people with aggressive lymphomas, cure is possible. For people with indolent lymphomas, treatment, when needed, extends life and relieves symptoms for many years. The likelihood of a cure or long-term survival depends on the type of non-Hodgkin lymphoma and the stage when treatment starts. It is somewhat of a paradox that indolent lymphomas usually respond readily to treatment by going into remission (in which the disease is under control), often followed by long-term survival, but the disease usually is not cured. In contrast, aggressive non-Hodgkin lymphomas, which usually require very intensive treatment to achieve remission, have a good chance of being cured.
Stage I and II Non-Hodgkin Lymphomas: People with indolent lymphomas who have very limited disease (stages I and II) are often treated with radiation therapy limited to the site of the lymphoma and adjacent areas. With this approach, most people do not have a disease recurrence in the irradiated area. Non-Hodgkin lymphomas can recur elsewhere in the body as long as 10 years after treatment, so people require long-term monitoring. People with aggressive lymphomas at a very early stage need to be treated with combination chemotherapy and sometimes radiation therapy. With this approach, 70 to 90% of people are cured.
Stage III and IV Non-Hodgkin Lymphomas: Almost all people with indolent lymphomas have stage III or IV disease. They do not always require treatment initially, but they are monitored for evidence of lymphoma progression, which could signal a need for therapy, sometimes years after the initial diagnosis. There is no evidence that early treatment extends survival in people with indolent lymphomas at more advanced stages. If the disease begins to progress, there are many treatment choices.
It is not known which treatment option is best initially, so the choice of treatment is influenced by the extent of disease and the person's symptoms. Treatment may include therapy with monoclonal antibodies (
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]Some Trade Names
RITUXAN
) alone or chemotherapy with or without
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]Some Trade Names
RITUXAN
. These antibodies are given intravenously. Sometimes, the monoclonal antibodies are modified so that they can carry radioactive particles or toxic chemicals directly to the cancer cells in different parts of the body. Treatment usually produces a remission. The average length of remission ranges from 2 years to more than 5 years. When
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]Some Trade Names
RITUXAN
is combined with chemotherapy, the results of remission are better. The roles of maintenance chemotherapy (chemotherapy given after the initial treatment to help prevent relapse) and combined chemotherapy plus radioimmunotherapy are being studied.
A decision about treatment after a relapse (in which lymphoma cells reappear) depends on the extent of the disease and the symptoms. If non-Hodgkin lymphoma relapses, a type of radiation therapy called radioimmunotherapy is an option. After an initial relapse, remissions tend to become shorter.
For people with aggressive stage III or IV non-Hodgkin lymphomas, combinations of chemotherapy drugs are given promptly, often together with
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]Some Trade Names
RITUXAN
. Many potentially effective combinations of chemotherapy drugs are available. Combinations of chemotherapy drugs are often given names created by using single letters from each of the drugs that are included. For example, one of the oldest and still one of the most commonly used combinations is known as CHOP (
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]Some Trade Names
LYOPHILIZED CYTOXAN
, [hydroxy]
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]Some Trade Names
DOXIL
, vincristine [Oncovin], and prednisone).
[ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]Some Trade Names
RITUXAN
has been shown to improve the outcome of CHOP and is now routinely added to the combination (R-CHOP). More than 70% of people with aggressive non-Hodgkin lymphomas at an advanced stage are cured with R-CHOP chemotherapy. Newer combinations of drugs are being studied. Chemotherapy, which often causes different types of blood cells to decrease in number, is sometimes better tolerated if special proteins (called growth factors) are also given to stimulate growth and development of blood cells.
Relapse: Chemotherapy at usual doses is of very limited value when relapse occurs. Many people who have a relapse of an aggressive lymphoma receive high doses of chemotherapy drugs combined with autologous stem cell transplantation, involving the person's own stem cells ). With this type of treatment, up to 50% of people may be cured. Sometimes stem cells from a sibling or even an unrelated donor (allogeneic transplant) can be used, but this type of transplantation has a greater risk of complications.